Pengaruh Pemilihan Anti-Psikotik Pada Pasien Depresi Tanpa dan Dengan Gejala Psikotik Terhadap Lama Hari Rawat Inap

Palupi Poppy Diah, Buanasari Buanasari


Antipsychotic therapy is given frequently to the patient with depressive symptoms. Antipsychotics are used to enhance the effects of antidepressants in the depressive patients. The aim of this study was to evaluate the length of stay of antipsychotic therapy selection in the depressive patient without/with psychosis symptoms. This study was conducted by quantitative method, multicenter, non-experimental approach, and cohort design study. Data were collected from medical records of 187 patients diagnosed with depression without/with psychosis symptoms from the various mental-illness hospital in Central Java Province. There was a significant difference (p <0.05) in the length of stay with the selection of antidepressants in depressive patients without psychotic symptoms, and there was no significant difference (p> 0.05) in the length of stay with the selection of antipsychotic agents in depressive patients without/with psychotic symptoms.

Keywords— Length of stay, depression, without/with psychosis symptoms, antipsychotic

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V.A SBJ dan S. Depression and Bipolar Disorder. In: A

Grebb Jack, editor. Kaplan & Sadock’s Synopsis of

Psychiatry: Behavioral Sciences/Clinical Psychiatry.

th Edition, Lippincott Williams & Wilkins; 2007, p.


American Psychiatric Association. Mood Disorder.

Diagnostic and Statistical Manual of Mental Disorder.

th edition, Washington DC: Text Revision; 2000.

Barbosa L, Berk M, Vorster M. A double-blind,

randomized, placebo-controlled trial of augmentation

with lamotrigine or placebo in patients concomitantly

treated with fluoxetine for resistant major depressive

episodes. The Journal of Clinical Psychiatry


Kennedy SH, Lam RW. Enhancing outcomes in the

management of treatment-resistant depression: a focus

on atypical antipsychotics. Bipolar Disorders 2003;5:36–


Keck PE. Bipolar depression: a new role for atypical

antipsychotics? Bipolar Disorders 2005;7:34–40.


McIntyre RS, Filteau M-J, Martin L, Patry S, Carvalho

A, Cha DS, et al. Treatment-resistant depression:

Definitions, review of the evidence, and algorithmic

approach. Journal of Affective Disorders 2014;156:1–7.


Keck, P. E., Jr., Strakowski, S. M., & McElroy SL. The

efficacy of atypical antipsychotics in the treatment of

depressive symptoms, hostility, and suicidality in

patients with schizophrenia. The Journal of Clinical

Psychiatry 2000;61:4–9.

Tohen M, Zhang F, Taylor CC, Burns P, Zarate C,

Sanger T, et al. A meta-analysis of the use of typical

antipsychotic agents in bipolar disorder. Journal of

Affective Disorders 2001;65:85–93. doi:10.1016/S0165-


Rothschild AJM, Williamson DJMb, Tohen MFM,

Schatzberg A, Anderson S, Van Campen LE, et al. A

Double-Blind, Randomized Study of Olanzapine and

Olanzapine... : Journal of Clinical Psychopharmacology.

Journal of Clinical Psychopharmacology 2004;Volume


Ussher JM. Are We Medicalizing Women’s Misery? A

Critical Review of Women’s Higher Rates of Reported

Depression. Feminism & Psychology 2010;20:9–35.


Bangasser DA, Curtis A, Reyes BAS, Bethea TT,

Parastatidis I, Ischiropoulos H, et al. Sex differences in

corticotropin-releasing factor receptor signaling and

trafficking: potential role in female vulnerability to

stress-related psychopathology. Molecular Psychiatry

;15:896–904. doi:10.1038/mp.2010.66.

Douma SL, Husband C, O’Donnell ME, Barwin BN,

Woodend AK. Estrogen-related mood disorders:

reproductive life cycle factors. ANS Advances in

Nursing Science 2005;28:364–75.

Kessler RC. Epidemiology of women and depression.

Journal of Affective Disorders 2003;74:5–13.


Bennett HA, Einarson A, Taddio A, Koren G, Einarson

TR. Prevalence of Depression During Pregnancy:

Systematic Review. Obstetrics & Gynecology



Bogner HR, Gallo JJ. Are higher rates of depression in

women accounted for by differential symptom reporting?

Social Psychiatry and Psychiatric Epidemiology

;39:126–32. doi:10.1007/s00127-004-0714-z.

Ismail SK. Gangguan Depresi. Buku Ajar Psikiatri,

Jakarta: Fakultas Kedokteran Universitas Indonesia;

Buysse DJ, Angst J, Gamma A, Ajdacic V, Eich D,

Rössler W. Prevalence, Course, and Comorbidity of

Insomnia and Depression in Young Adults. Sleep

;31:473–80. doi:10.1093/sleep/31.4.473.

Stahl SM. Mechanism of action of serotonin selective

reuptake inhibitors. Serotonin receptors and pathways

mediate therapeutic effects and side effects. Journal of

Affective Disorders 1998;51:215–35.

Hirschfeld RMA. Efficacy of SSRIs and newer

antidepressants in severe depression: comparison with

TCAs Authors’ objectives Methods of synthesis How

were the studies combined? Journal of Clinical

Psychiatry 1999. doi:DOI:10.4088/JCP.v60n0511.

Vasant S. A prospective comparative study on

tolerability and safety of amitryptiline and fluoxetine in

patients with depression. World Journal of

Pharmaceutical Research 2016;5:934–42.

Nierenberg AA. The treatment of severe depression: Is

there an efficacy gap between SSRI and TCA

antidepressant generations? The Journal of Clinical

Psychiatry 1994;55:55–9.

Anton RF Jr BEJ. Amoxapine versus amitriptyline

combined with perphenazine in the treatment of

psychotic depression. American Journal of Psychiatry

;147:1203–8. doi:10.1176/ajp.147.9.1203.

Bondolfi G, Eap C, Bertschy G, Zullino D, Vermeulen

A, Baumann P. The Effect of Fluoxetine on the

Pharmacokinetics and Safety of Risperidone in Psychotic

Patients. Pharmacopsychiatry 2002;35:50–6.


Hillert A, Maier W, Wetzel H, Benkert O. Risperidone

in the Treatment of Disorders with a combined Psychotic

and Depressive Syndrome - A Functional Approach.

Pharmacopsychiatry 1992;25:213–7. doi:10.1055/s-


Wu C-S, Hsieh MH, Tang C-H, Chang C-J. Comparative

effectiveness of long-acting injectable risperidone vs.

long-acting injectable first-generation antipsychotics in

bipolar disorder. Journal of Affective Disorders

;197:189–95. doi:10.1016/J.JAD.2016.03.043.



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