REVIEW : AKTIVITAS ANTIHIPERGLIKEMIK DAN HIPOLIPIDEMIK EKSTRAK PEPAYA ( Carica papaya Linn ) TERHADAP TIKUS DIABETES YANG DI INDUKSI OLEH ALOKSAN DAN GLIBENKLAMID

Sukmawati Sukmawati, Yaswinar Susilawati, Tiana Milanda

Abstract


Diabetes adalah gangguan metabolisme pada tubuh disebabkan abnormalitas sekresi insulin, kerja insulin atau keduanya, yang ditandai dengan gangguan  metabolisme karbohidrat, lemak, dan protein. Satu satu tumbuhan obat yang memiliki aktivitas antihiperglikemik dan hipolipidemikadalah pepaya(CaricapapayaLinn).Dari hasil review beberapa artikel diketahui bahwa ekstrak air  biji pepaya. ekstrak air daun  pepaya dan ekstrak metanol kulit batang pepaya menunjukkan adanya aktivitas antihiperglikemik. Waktu  penelitian bervariasi selama 21 dan 30 hari, menggunakan tikus yang diinduksi oleh aloksan dan glibenklamid. Dosis efektif pada pengujian ekstrak air biji pepaya dan ekstrak daun pepaya adalah   400 mg/kg bb, sedangkan dosis efektif pada ekstrak metanol kulit batang pepaya adalah 500 mg/kg bb

Full Text:

References


S.O. Olabanji, A.C. Adebanjo, O.R. Omobuwajo, D. Ceccato, M.C. Buoso, G. Moschini., 2014, Analysis of some Nigerian anti-diabetic medicinal plants (II), B 318 187-190

F. Raffaelli, L. Naneti, G. Montecchiani, F. Borroni, E. Salvolini, E. Falolia, dkk, 2015, In vitro effect of fermented papaya ( Carica papaya, L) on platelets obtained from patiens with type 2 diabetes, Nutrition, Metabolism & Cardiovascular Diseases, 25, 224-229.

Yasmeen Maniyar, Prabhu Bhixavatimah., 2012, Antihyperglycemic and hypolipidemic activities of aqueous exstract of carica papaya Linn. Leaves in alloxan-induced diabetic rats, Journal of Ayurveda & Integrative Medicine 3, (2)

Isela Esther Juares-Rojop, Juan C Diaz-Zagoya, Jorge L Ble Castillo., 2012, Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats, Juares – Rojop et al BMC Complementary and Alternative Medicine, 12:236.

Adeneye, A. A.; Olagunju, J. A., 2009, Preliminary Hypoglycemic and Hypolipidemic Activities of the Aqueous Seed Extract of Carica Papaya Linn. In Wistar Rats. Biology and Medicine, 1 (1), 1–10.

Tandi Herbie., 2015 Kitab Tanaman Berkhasiat Obat 226 tumbuhan obat untuk menyembuhkan penyakit dan kebugaran tubuh, Edisi Pertama, Octopus Publishing House, Yogyakarta

Isela Esther Juares-Rojop, Juan C Diaz-Zagoya, Jorge L Ble Castillo., 2012, Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats, Juares – Rojop et al BMC Complementary and Alternative Medicine, 12:236.

Cahya S, Rini Susiana., 2016, Grow Your Own Medical Plant – Panduan Praktis Menanam 51 Tanaman Obat Popular di Pekarangan, Edisi pertama, Lily publisher, Yogyakarta

Vij Tarun, Yash Prashar., 2015 A review on medicinal properties of Carica papaya Linn. Asian Pac Journal of Tropical Disease 5(1) , 1-6.

Saidu, A. N and Nweri, C. G., 2013,, Phytochemical Screening and Effects of Methanol Extract of Carica papaya stem bark in alloxan induced Diabetic Rats, Journal Of Emergining Trends in Engineering Aplied Sciences 4 (6), 819–822.




DOI: http://dx.doi.org/10.30591/pjif.v7i2.986

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Parapemikir : Jurnal Ilmiah Farmasi

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License

 My Counter

.

 

 

===============================================================

 

 

 

Indexed By: